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The prognosis for most patients is very good. The Official publication of the Spanish Academy of Dermatology and Venereology (AEDV). In the year 2006 has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern.

All articles are subjected to a rigorous Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum of revision in pairs, and careful editing for literary and scientific style. Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews.

Subacute cutaneous lupus erythematosus (SCLE) is a variant of photosensitive cutaneous lupus erythematosus that is often associated with anti-Ro antibodies. Patient 1 was a 54-year-old woman (smoker) diagnosed with SCLE.

She had annular lesions on her back (Fig. A, Patient with extensive subacute cutaneous lupus erythematosus lesions before starting therapy with rituximab. B, The patient is lesion-free 8 months after her fourth cycle of rituximab. Improvement was partial, and the patient experienced the following side effects: blurred vision (antimalarial penis shrinking, sensory axonal polyneuropathy (thalidomide), and leukopenia (cyclophosphamide).

Remission was complete after 2 months. Patient 2 was a 37-year-old woman (smoker) with Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum, for which she was receiving carbamazepine but later nih fodd to valproic acid.

She had been diagnosed with SCLE at age 34 years and had annular lesions on her upper chest, back, and arms. Her skin lesions worsened considerably when azathioprine was stopped (Fig. The patient progressed favorably, with no active lesions after 3 months. A, Patient with extensive Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum subacute cutaneous lupus erythematosus lesions before starting therapy with rituximab.

B, Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum patient is lesion-free 8 months after her second cycle of rituximab. Patient 3 was a 28-year-old woman who consulted with malar rash, asthenia, arthritis, low-grade fever, and annular lesions on the upper chest, back, and arms.

Skin biopsy confirmed a clinical diagnosis of SCLE. The response was good, although her condition deteriorated when the dose of corticosteroid was reduced. Two months later, the patient's skin and clinical symptoms had improved considerably, although the malar rash persisted on the center of her face.

Treatment of SCLE is based on strict photoprotection and administration of antimalarial agents as the first-line systemic approach. The duration of the drug's effectiveness varies, and it usually lasts from at least 5 months to around 14 months. The improvement in skin lesions was both marked and persistent. The same dose was administered a year later because the lesions recurred. We present 3 cases of refractory SCLE treated successfully with rituximab, which was well tolerated.

Limited published experience and our findings in the present manuscript allow us to propose rituximab as an alternative for treatment of SCLE refractory to rain johnson usual approaches.

However, larger-scale studies will Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum us to set limits for this indication and establish the safety profile in this group of patients. Please cite this article as: D. Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological and genetic findings.

Autoimmun Rev, 4 (2005), pp. Lupus, 19 (2010), pp. Rituximab: A promising therapy in systemic lupus erythematosus. Autoimmun Rev, 5 (2006), pp. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. Ann Oncol, 14 (2003), pp. Best Pract Res Bupivacaine Hydrochloride and Epinephrine Injection (Marcaine)- Multum Rheumatol, 24 (2010), pp.

Int J Dermatol, 45 (2006), pp. Safety and Efficacy of Rituximab in Systemic Lupus Erythematosus.

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Comments:

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