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Finally, this ester is hydrolyzed vans johnson simultaneously cyclized by means of NaH in DMF to provide the target intermediate vans johnson. Other acyl chlorides vans johnson as (S)-2-(4-isobutylphenyl)propionyl chloride, (S)-O-acetylmandeloyl chloride, (S)-benzyloxycarbonylprolyl chloride, (S)-2-phenylbutyryl chloride, (S)-2-methoxy-2-phenylacetyl chloride or (S)-N-acetylalanine can also be used in the vans johnson sequence.

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